Reproduction Abstracts

Polycystic ovary syndrome, a common endocrine condition affecting up to 10% of women of reproductive age, is associated with an increased risk of developing insulin resistance and obesity. Obesity is associated with increased energy intake or reduced energy expenditure. In this context, postprandial thermogenesis (PPT), is an important constituent of energy expenditure.Our lab utilizes a clinically realistic ovine model of PCOS, where pregnant Scottish G...

Some adult diseases are programmed in utero by fetal exposure to abnormal concentrations of steroid hormones. Threatened miscarriage in early pregnancy is treated by progesterone in many countries although robust evidence of efficacy is lacking. We hypothesised that increased progesterone concentrations may alter fetal development. In a small pilot study, using a pregnant sheep model, we administered 200 mg progesterone twice weekly from d20–d75 of gestation and ...

Women with Polycystic Ovary Syndrome are at increased risk of developing insulin resistance, obesity and dyslipidemia. Amplified metabolic perturbations during puberty may be a central factor contributing to metabolic phenotype of adult PCOS. Using a clinically realistic ovine model of PCOS we reported hyperinsulinaemia and early fatty liver changes, with no difference in body weight and adiposity, in adolescence.Here we aimed to further examine metaboli...